Contract Manufacturing of Effervescent Tablets

Effervescent tablets dissolve upon contact with water to release carbon dioxide and create a drink. We design and manufacture effervescent tablets that have a pleasant taste, even if they contain bitter, sulfuric, sour, metallic, astringent, or difficult-to-process APIs. All our effervescent products dissolve quickly and completely leaving no residues or foam.

The composition of our effervescent tablets helps to speed up the absorption of APIs, so they are already dissolved when entering the body. By creating a buffered solution that increases the pH value of the stomach, APIs are then quickly passed to the small intestine. Our effervescent tablets are extremely stable, meaning they are less sensitive to humidity and high temperatures and can be used in tropical regions (climatic zones III- IV).

Manufacturing expertise

To deliver the benefits described above, effervescent tablets (and instant drinks) must dissolve quickly and completely upon contact with water. Furthermore, to enhance patient experience, they should dissolve without leaving unpleasant residues or foam on the surface that can impact on taste or mouthfeel.

The development of effervescent products requires specific expertise and dedicated manufacturing conditions. As they are particularly susceptible to moisture, environmental humidity must be carefully controlled at all times.

At Helenz Pharmaceutical, we use to facilitate the formulation of even very sensitive APIs into stable effervescent tablets and effervescent instant drinks with a shelf-life of up to five years. Many APIs are sensitive to moisture, oxygen, light, and acidic/alkaline micro-environments. We passivate the citric acid or bicarbonate using TOPO granulation thereby avoiding such micro-environments and producing effervescent products that are quickly and completely soluble while, at the same time, extremely resistant to humidity in the atmosphere. Inline packaging reduces unnecessary exposure to humidity.

We also employ our flavoring expertise to give our products a taste that patients will enjoy. Find out more about effervescent tablets and how our TOPO technology helps to manufacture stable products that ensure a pleasant patient experience:

Effervescent tablets are at the core of Helenz Pharmaceutical's expertise. We are recognized in the healthcare industry as the biggest and most experienced manufacturer of high-quality effervescent tablets.